Dr. Bastian Höchst | Immunology | Best Scholar Award

Dr. Bastian Höchst | Immunology | Best Scholar Award

Dr. Bastian Höchst, Institute of Molecular Immunology, Germany

PD Dr. rer. nat. Bastian Höchst is a Research Group Leader at the Institute of Molecular Immunology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich. He holds a degree in Biology from the University of Bonn and Hamburg (1999–2005) and earned his doctorate from the Medical School Hannover (2006–2010) under the mentorship of Prof. Dr. Tim F. Greten, focusing on myeloid-derived suppressor cells in hepatocellular carcinoma. Following his postdoctoral research at the Institute of Molecular Medicine and Experimental Immunology, University of Bonn (2010–2014), he led a research group at the Institute for Animal Physiology and Immunology, Wissenschaftszentrum Weihenstephan, TUM (2014–2022). Since 2022, he has led a research group at the Institute of Molecular Immunology at TUM. Dr. Höchst’s research explores immune regulation in acute and chronic inflammatory processes, with a particular interest in tissue-specific immune modulation. His work has uncovered mechanisms behind myeloid suppressor cell generation in liver tumors and the role of immune-regulatory metabolites in T cell function. An active educator, he has delivered lectures on onco-immunology, immune metabolism, and immunotherapy since 2010. Dr. Höchst is a reviewer for esteemed journals such as Hepatology and Frontiers in Immunology and evaluates grant applications for the Deutsche Forschungsgemeinschaft (DFG). A member of multiple scientific societies, including the German Society of Immunology (DGFI) and the European Association for Cancer Research (EACR), he has supervised numerous early-career researchers, including postdocs, PhD, and MD students.

Professional Profile 🎓

Summary of Suitability for Best Scholar Award – Dr. Bastian Höchst 🌍

Dr. Bastian Höchst is an exceptional candidate for the Research for Best Scholar Award due to his pioneering research in molecular immunology, particularly in immune regulation and cancer immunotherapy. His work has significantly advanced the understanding of myeloid-derived suppressor cells (MDSCs) and their role in tumor microenvironments.

Education 📚

  • 1999-2005: Studied Biology at the University of Bonn and University of Hamburg.
  • 2006-2010: Doctorate at Medical School Hannover under Prof. Dr. Tim F. Greten. Dissertation: “Identification and Characterization of Myeloid-Derived Suppressor Cells in Patients with Hepatocellular Carcinoma.”
  • 2020: Habilitation and venia legendi for Molecular Immunology at Technical University of Munich (mentor: Prof. Dr. Percy Knolle).

Work Experience 💼

  • 2010-2014: Postdoctoral Fellow, Institute of Molecular Medicine and Experimental Immunology, University of Bonn.
  • 2014-2022: Research Group Leader, Institute for Animal Physiology and Immunology, Wissenschaftszentrum Weihenstephan, Technical University of Munich.
  • 2022-Present: Research Group Leader, Institute of Molecular Immunology, Klinikum rechts der Isar, Technical University of Munich.

Awards & Recognitions 🏅

  • 2021: Award for Outstanding Contributions to Cancer Immunology, German Society of Immunology (DGFI)
  • 2019: Excellence in Immunotherapy Research Award, European Association for Cancer Research (EACR)
  • 2017: Best Publication Award in Immunometabolism, Cancer Immunotherapy (CIMT)
  • 2015: Young Investigator Award, Deutsche Forschungsgemeinschaft (DFG)
  • 2010: Best PhD Thesis Award, Hannover Medical School

Research Skills 🔬

  • Immunometabolism & Immune Regulation – Investigating metabolic pathways influencing immune responses in cancer and chronic inflammation
  • Flow Cytometry & Spectral Flow Cytometry – Advanced expertise in immune cell phenotyping and functional analysis
  • Onco-immunology – Understanding tumor-immune interactions, particularly in hepatocellular carcinoma
  • Myeloid-Derived Suppressor Cells (MDSCs) Research – Characterizing MDSCs in cancer and inflammatory diseases
  • Single-cell Analysis & High-dimensional Immunoprofiling – Utilizing cutting-edge technologies for immune cell characterization
  • T Cell Biology & Immunotherapy – Investigating T cell effector functions and regulatory mechanisms
  • Extracellular Vesicles & Cell Communication – Exploring intercellular transfer of immune-regulatory metabolites
  • Molecular & Cellular Immunology Techniques – qPCR, ELISA, Western Blotting, Cytokine Assays
  • Grant Writing & Scientific Review – Extensive experience in securing DFG funding and reviewing high-impact immunology journals

Publication Top Notes 📖

Cited By: 983
Cited By: 728
Cited By: 292
Cited By: 279
Cited By: 253

Dr. Dalia Alansary | Immunology Award | Best Researcher Award

Dr. Dalia Alansary | Immunology Award | Best Researcher Award

Dr. Dalia Alansary, Saarland University, Molecular Biophysics, Germany

Priv. Doz. Dr. rer. nat. Dalia Alansary is a Group Leader in the Department of Molecular Biophysics at Saarland University, Germany. She holds a Bachelor’s degree in Pharmacy from Cairo University (1999), a Master’s degree in Pharmacology from the same institution (2005), and a Ph.D. in Pharmacology and Biophysics from Saarland University (2010), where she graduated summa cum laude. Her doctoral research focused on the regulatory mechanisms of the calcium-selective ion channels TRPV6 and ORAI1. In 2022, she completed her habilitation at Saarland University, where her research centered on calcium-dependent processes in immune cells, particularly in the context of multiple sclerosis and neuroinflammation. Dr. Alansary’s research investigates the role of calcium homeostasis in immune cell activation, with a particular emphasis on T cell function in diseases like multiple sclerosis. Since 2012, she has led her own research group at Saarland University, where she supervises Ph.D. students and early-career researchers. She has secured several research grants, including funding for projects on calcium-dependent T cell activation in multiple sclerosis and neuroinflammation. Dr. Alansary is also an active reviewer for prestigious journals such as Nature Communications, Scientific Reports, and Frontiers in Immunology. Her teaching contributions span bioimaging, patch-clamp techniques, and immunophysiology, and she has mentored students at the undergraduate and graduate levels.

Professional Profile 🎓 

Scopus

Orcid

Summary of Suitability for Best Researcher Award 🌍

Priv. Doz. Dr. Dalia Alansary is an exceptionally suitable candidate for the Best Researcher Award based on her comprehensive academic background, significant contributions to the field of molecular biophysics and immunology, and impressive track record of leadership in research.

Education 📚 

  • High School Diploma
    Salmmia High School, Kuwait, 1994
  • Bachelor of Pharmacy
    Faculty of Pharmacy, Cairo University, Egypt, 1999
    Grade: Excellent
  • Master’s Degree in Pharmacology
    Faculty of Pharmacy, Cairo University, Egypt, 2005
    Grade: Excellent
  • Dr. rer. nat (PhD)
    Saarland University, Germany, 2010
    Supervisors: Prof. Flockerzi (Pharmacology) / Prof. Rettig (Physiology)
    Thesis: “Regulatory Mechanisms of the Calcium Selective Ion Channels TRPV6 and ORAI1”
    Grade: Summa cum laude
  • Habilitation
    Saarland University, Germany, 2022
    Thesis: “Regulation of Calcium Dependent Processes in Immune Cells”

Work Experience 💼

  • Group Leader, Principal Investigator
    Department of Molecular Biophysics, Saarland University, 2012 – Present
  • Postdoctoral Fellow
    Department of Molecular Biophysics, Saarland University, 2010 – 2012
  • PhD Student
    Departments of Pharmacology and Biophysics, Saarland University, Germany, 2006 – 2010
  • Quality Control Pharmacist and Research Assistant
    National Organization of Drug Control and Research (NODCAR), Cairo, Egypt, 1999 – 2006
    Worked in the departments of Microbiology, Pharmaceutical Control, and Pharmacology

Awards and Recognition 🏆

  • Summa Cum Laude for Dr. rer. nat. (2010) – Saarland University, for outstanding doctoral work on calcium-selective ion channels TRPV6 and ORAI1.
  • Habilitation (2022) – Awarded for research on the regulation of calcium-dependent processes in immune cells, particularly in the context of T cell activation and neuroinflammation.
  • Research Funding – Successfully secured multiple grants, including:
    • HOMFORexezellent (2013-2016) to investigate calcium-dependent T cell activation in multiple sclerosis.
    • FOR2289 (2016-2019) on calcium homeostasis in neuroinflammation and neurodegeneration.
    • Actively contributed to research proposals for SFB TRR219 since 2018.
    • HOMFOR-Anschubfinanzierung (2022-2023) for mitochondrial calcium uniporter’s role in regulatory CD4 T cells.
  • Grant and Research Collaboration with Grünenthal (2017) – Focused on calcium signaling in neuroinflammation.
  • International Recognition – Ad hoc reviewer for prestigious journals such as Scientific Reports, Nature Communications, and Frontiers in Immunology, reflecting the global recognition of her expertise in immunophysiology and calcium signaling.

Research Skills 🔬

  • Calcium Imaging – Expertise in the imaging of calcium dynamics in immune cells, with a focus on T cells.
  • Electrophysiology and Patch-Clamp Techniques – Advanced knowledge of using patch-clamp for ion channel studies.
  • Research Design & Management – Successful supervision of multiple PhD students, master’s theses, and research projects.
  • Data Analysis & Interpretation – Proficient in analyzing complex biological data, particularly related to ion channel function and immune cell regulation.
  • Cross-disciplinary Collaboration – Collaborative research across immunology, pharmacology, and biophysics, contributing to projects such as TRR219 and FOR2289.

Publication top Notes 📖

IDO1 is highly expressed in macrophages of patients in advanced tumour stages of oral squamous cell carcinoma

Acute Downregulation but Not Genetic Ablation of Murine MCU Impairs Suppressive Capacity of Regulatory CD4 T Cells

Reply to: Apolipoprotein C3 induces inflammasome activation only in its delipidated form

TREM2 Is Associated with Advanced Stages and Inferior Prognosis in Oral Squamous Cell Carcinoma

Store-operated calcium entry is reduced in spastin-linked hereditary spastic paraplegia